No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
468 |
4. Check minimum number of eventsNone |
468 |
5. Include endpointsNone |
468 |
6. Filter based on genotype QC (FinnGen only) |
457 |
Control definitions (FinnGen only)
Control exclude
F5_SLEEP
Extra metadata
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Hypersomnia
based on the number of shared cases.
Similar with more cases:
- Sleep disorders
- Behavioural syndromes associated with physiological disturbances and physical factors
- Sleep disorders (combined)
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2929 | 1404 | 1508 |
| Only index persons | 2812 | 1368 | 1444 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.05 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 43.74 | 39.88 | 47.34 |
| Only index persons | 43.55 | 39.80 | 47.10 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 457 | 265 | 192 |
| Unadjusted period prevalence (%) | 0.10 | 0.10 | 0.10 |
| Median age at first event (years) | 45.09 | 42.49 | 48.67 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint F5_HYPERSOMNIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_HYPERSOMNIA | 1.495 [1.17, 1.91] | 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.241 |
During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 1255 females with F5_HYPERSOMNIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_HYPERSOMNIA | 1.255 [1.08, 1.45] | 0.003 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 1339 males with F5_HYPERSOMNIA died.
Mortality risk
Mortality risk for people of age
years, who have F5_HYPERSOMNIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.177% | 0.207% |
| 5 | 0.948% | 1.378% |
| 10 | 2.469% | 3.501% |
| 15 | 4.569% | 6.807% |
| 20 | 7.849% | 11.469% |
Relationships between endpoints
↥Index endpoint: F5_HYPERSOMNIA – Hypersomnia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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