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Other eating disorders

DOID EFO Endpoint Browser PheWeb

F5_EATOTH

eating disorder: A broad group of psychological disorders with abnormal eating behaviors leading to physiological effects from overeating or insufficient food intake.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F50
  • Hospital discharge: ICD-9 — 3075
  • Hospital discharge: excluded ICD-10 — F50.0, F50.1, F50.2, F50.3
  • Hospital discharge: excluded ICD-9 — 3075A
  • Cause of death: ICD-10 — F50
  • Cause of death: ICD-9 — 3075
  • Cause of death: excluded ICD-10 — F50.0, F50.1, F50.2, F50.3
  • Cause of death: excluded ICD-9 — 3075A

2 out of 7 registries used, show all original rules.

2030

4. Check minimum number of events

None

2030

5. Include endpoints

None

2030

6. Filter based on genotype QC (FinnGen only)

1941

Control definitions (FinnGen only)

Control exclude F5_BEHAVE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F50-F59
Name in latin Perturbationes edendi

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19921 17070 2777
Only index persons 18958 16525 2433
Unadjusted period prevalence (%)
Whole population 0.43 0.49 0.08
Only index persons 0.54 0.61 0.09
Median age at first event (years)
Whole population 18.12 18.14 17.60
Only index persons 17.97 18.06 17.30

-FinnGen-

Key figures

All Female Male
Number of individuals 1941 1746 195
Unadjusted period prevalence (%) 0.63 0.69 0.10
Median age at first event (years) 23.58 22.57 32.60

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_EATOTH and mortality.

Females

Parameter HR [95% CI] p-value
F5_EATOTH 2.97 [2.39, 3.69] < 0.001
Birth year 0.998 [0.99, 1.01] 0.568

During the follow-up period (1.1.1998 — 31.12.2019), 554 out of 14118 females with F5_EATOTH died.

Males

Parameter HR [95% CI] p-value
F5_EATOTH 3.202 [2.4, 4.27] < 0.001
Birth year 0.989 [0.98, 1.0] 0.024

During the follow-up period (1.1.1998 — 31.12.2019), 336 out of 2302 males with F5_EATOTH died.

Mortality risk

Mortality risk for people of age

years, who have F5_EATOTH.

N-year risk Females Males
1 0.372% 0.71%
5 2.025% 4.507%
10 4.697% 10.503%
15 9.267% 18.197%
20 15.444% 29.237%

Relationships between endpoints

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Index endpoint: F5_EATOTH – Other eating disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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