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Dissociative [conversion] disorders

DOID EFO Endpoint Browser PheWeb

F5_DISSOCIATIVE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F44
  • Hospital discharge: ICD-9 — 3001
  • Hospital discharge: ICD-8 — 3001
  • Cause of death: ICD-10 — F44
  • Cause of death: ICD-9 — 3001
  • Cause of death: ICD-8 — 3001

2 out of 7 registries used, show all original rules.

1462

4. Check minimum number of events

None

1462

5. Include endpoints

None

1462

6. Filter based on genotype QC (FinnGen only)

1384

Control definitions (FinnGen only)

Control exclude F5_NEUROTIC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 F40-F48
Name in latin Perturbationes dissociativae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12572 9314 3127
Only index persons 11171 8499 2672
Unadjusted period prevalence (%)
Whole population 0.22 0.27 0.09
Only index persons 0.26 0.31 0.10
Median age at first event (years)
Whole population 31.81 31.31 32.96
Only index persons 30.04 29.75 30.94

-FinnGen-

Key figures

All Female Male
Number of individuals 1384 1123 261
Unadjusted period prevalence (%) 0.38 0.44 0.13
Median age at first event (years) 31.90 30.93 36.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint F5_DISSOCIATIVE and mortality.

Females

Parameter HR [95% CI] p-value
F5_DISSOCIATIVE 2.254 [1.9, 2.67] < 0.001
Birth year 1.0 [0.99, 1.01] 0.914

During the follow-up period (1.1.1998 — 31.12.2019), 344 out of 5610 females with F5_DISSOCIATIVE died.

Males

Parameter HR [95% CI] p-value
F5_DISSOCIATIVE 2.168 [1.69, 2.78] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 205 out of 1845 males with F5_DISSOCIATIVE died.

Mortality risk

Mortality risk for people of age

years, who have F5_DISSOCIATIVE.

N-year risk Females Males
1 0.182% 0.393%
5 1.203% 2.231%
10 3.47% 5.768%
15 6.911% 10.289%
20 12.166% 17.703%

Relationships between endpoints

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Index endpoint: F5_DISSOCIATIVE – Dissociative [conversion] disorders

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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