bulimia nervosa: A disorder characterized by recurrent episodes of binge-eating over which the individual feels a lack of control; these episodes of binge-eating are followed by recurrent compensatory behavior to prevent weight gain, usually self-induced vomiting. In addition, self-evaluation is unduly influenced by body image.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1319 |
4. Check minimum number of eventsNone |
1319 |
5. Include endpointsNone |
1319 |
6. Filter based on genotype QC (FinnGen only) |
1262 |
Control definitions (FinnGen only)
Control exclude
F5_BEHAVE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Bulimia nervosa (incl. atypical)
based on the number of shared cases.
Similar with more cases:
- KRA_PSY_EATING
- KRA_PSY_EATING
- Eating disorders
- Behavioural syndromes associated with physiological disturbances and physical factors
- Exclusions for E4_PCOS_CONSORTIUM
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9535 | 9072 | 424 |
| Only index persons | 9255 | 8860 | 395 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.25 | 0.26 | 0.01 |
| Only index persons | 0.31 | 0.33 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 22.20 | 21.96 | 27.11 |
| Only index persons | 22.11 | 21.91 | 26.79 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1262 | 1209 | 53 |
| Unadjusted period prevalence (%) | 0.46 | 0.47 | 0.03 |
| Median age at first event (years) | 24.19 | 23.91 | 30.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint F5_BULIMIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_BULIMIA | 3.263 [2.74, 3.88] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.37 |
During the follow-up period (1.1.1998 — 31.12.2019), 213 out of 7946 females with F5_BULIMIA died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have F5_BULIMIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.233% | No data |
| 5 | 1.831% | No data |
| 10 | 4.927% | No data |
| 15 | 9.511% | No data |
| 20 | 15.712% | No data |
Relationships between endpoints
↥Index endpoint: F5_BULIMIA – Bulimia nervosa (incl. atypical)
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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