This is a non-core endpoint: only basic statistics are computed.
Abuse of non-dependence-producing substances
F5_ABUNONDEP
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
44 |
4. Check minimum number of eventsNone |
44 |
5. Include endpointsNone |
44 |
6. Filter based on genotype QC (FinnGen only) |
41 |
Control definitions (FinnGen only)
Control exclude
F5_BEHAVE
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F50-F59
Name in latin
Abusus substantiarum dependentiam non producentium
Similar endpoints
↥List of similar endpoints to
Abuse of non-dependence-producing substances
based on the number of shared cases.
Similar with more cases:
- Behavioural syndromes associated with physiological disturbances and physical factors
- Any mental disorder
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 749 | 254 | 484 |
| Only index persons | 503 | 166 | 337 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 45.87 | 47.41 | 44.73 |
| Only index persons | 38.96 | 36.57 | 40.14 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 41 | 20 | 21 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 45.81 | 42.98 | 48.50 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint F5_ABUNONDEP and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_ABUNONDEP | 4.878 [3.14, 7.57] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 97 out of 279 males with F5_ABUNONDEP died.
Mortality risk
Mortality risk for people of age
years, who have F5_ABUNONDEP.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.902% |
| 5 | No data | 5.273% |
| 10 | No data | 12.758% |
| 15 | No data | 24.307% |
| 20 | No data | 38.78% |
Relationships between endpoints
↥Index endpoint: F5_ABUNONDEP – Abuse of non-dependence-producing substances
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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