No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditions
|
261775 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
4478 |
6. Filter based on genotype QC (FinnGen only) |
4232 |
Control definitions (FinnGen only)
Control conditions
not E4_PCOS_BROAD_EXCLUSIONS
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF6v3
Polycystic ovarian syndrome, broad definition
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 29153 | 29153 | - |
| Only index persons | 28858 | 28858 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.84 | 0.84 | - |
| Only index persons | 1.06 | 1.06 | - |
| Median age at first event (years) | |||
| Whole population | - | 29.08 | - |
| Only index persons | - | 29.06 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4232 | 4232 | - |
| Unadjusted period prevalence (%) | 1.66 | 1.66 | - |
| Median age at first event (years) | 29.47 | 29.47 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_PCOS_BROAD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PCOS_BROAD | 1.153 [0.97, 1.38] | 0.114 |
| Birth year | 0.993 [0.98, 1.0] | 0.087 |
During the follow-up period (1.1.1998 — 31.12.2019), 197 out of 23042 females with E4_PCOS_BROAD died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_PCOS_BROAD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.079% | No data |
| 5 | 0.583% | No data |
| 10 | 1.507% | No data |
| 15 | 2.982% | No data |
| 20 | 5.185% | No data |
Relationships between endpoints
↥Index endpoint: E4_PCOS_BROAD – Polycystic ovarian syndrome, broad definition
GWS hits: 8
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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