Female infertility, associated with anovulation

N14_FIANOV

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N97.0
  • Hospital discharge: ICD-9 6280
  • Cause of death: ICD-10 N97.0
  • Cause of death: ICD-9 6280

2 out of 7 registries used, show all original rules.

3367

4. Check minimum number of events

None

3367

5. Include endpoints

None

3367

6. Filter based on genotype QC (FinnGen only)

3182

Control definitions (FinnGen only)

Control exclude N14_FEMALEGENNONINF

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 N97
Name in latin Infertilitas feminae anovulatoria

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 21316 21316 -
Only index persons 21160 21160 -
Unadjusted period prevalence (%)
Whole population 0.61 0.61 -
Only index persons 0.78 0.78 -
Median age at first event (years)
Whole population - 29.83 -
Only index persons - 29.82 -

-FinnGen-

Key figures

All Female Male
Number of individuals 3182 3182 -
Unadjusted period prevalence (%) 1.25 1.25 -
Median age at first event (years) 29.91 29.91 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint N14_FIANOV and mortality.

Females

Parameter HR [95% CI] p-value
N14_FIANOV 0.686 [0.55, 0.85] < 0.001
Birth year 0.995 [0.99, 1.0] 0.273

During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 17266 females with N14_FIANOV died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_FIANOV.

N-year risk Females Males
1 0.077% No data
5 0.393% No data
10 1.04% No data
15 2.01% No data
20 3.325% No data

Relationships between endpoints

Index endpoint: N14_FIANOV – Female infertility, associated with anovulation

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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