The inability of female to get pregnant after a specified period of unprotected intercourse.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
13084 |
4. Check minimum number of eventsNone |
13084 |
5. Include endpoints |
17666 |
6. Filter based on genotype QC (FinnGen only) |
16720 |
Control definitions (FinnGen only)
Control exclude
N14_FEMALEGENNONINF
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N80-N98
Name in latin
Infertilitas feminae
Similar endpoints
↥List of similar endpoints to
Female infertility
based on the number of shared cases.
Similar with more cases:
- Noninflammatory disorders of female genital tract
- Genitourinary diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 115105 | 115105 | - |
| Only index persons | 113189 | 113189 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 3.30 | 3.30 | - |
| Only index persons | 4.16 | 4.16 | - |
| Median age at first event (years) | |||
| Whole population | - | 30.92 | - |
| Only index persons | - | 30.91 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 16720 | 16720 | - |
| Unadjusted period prevalence (%) | 6.57 | 6.57 | - |
| Median age at first event (years) | 31.11 | 31.11 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_FEMALEINFERT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_FEMALEINFERT | 0.867 [0.74, 1.02] | 0.088 |
| Birth year | 0.996 [0.99, 1.0] | 0.366 |
During the follow-up period (1.1.1998 — 31.12.2019), 574 out of 70381 females with N14_FEMALEINFERT died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_FEMALEINFERT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | No data |
| 5 | 0.524% | No data |
| 10 | 1.329% | No data |
| 15 | 2.569% | No data |
| 20 | 4.716% | No data |
Relationships between endpoints
↥Index endpoint: N14_FEMALEINFERT – Female infertility
GWS hits: 4
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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