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Disorders of parathyroid gland, other and/or unspecified

DOID EFO Endpoint Browser PheWeb

E4_PARANAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E21.4, E21.5, E21.5+M14.1
  • Hospital discharge: ICD-9 — 252[8-9]
  • Hospital discharge: ICD-8 — 2529
  • Cause of death: ICD-10 — E21.4, E21.5, E21.5+M14.1
  • Cause of death: ICD-9 — 252[8-9]
  • Cause of death: ICD-8 — 2529

2 out of 7 registries used, show all original rules.

229

4. Check minimum number of events

None

229

5. Include endpoints

None

229

6. Filter based on genotype QC (FinnGen only)

223

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1856 1425 415
Only index persons 1503 1173 330
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.01
Only index persons 0.04 0.04 0.01
Median age at first event (years)
Whole population 64.79 65.50 62.14
Only index persons 63.64 64.58 60.30

-FinnGen-

Key figures

All Female Male
Number of individuals 223 174 49
Unadjusted period prevalence (%) 0.06 0.07 0.02
Median age at first event (years) 60.08 60.08 60.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint E4_PARANAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_PARANAS 1.495 [1.3, 1.72] < 0.001
Birth year 0.993 [0.98, 1.0] 0.123

During the follow-up period (1.1.1998 — 31.12.2019), 411 out of 1112 females with E4_PARANAS died.

Males

Parameter HR [95% CI] p-value
E4_PARANAS 1.696 [1.3, 2.22] < 0.001
Birth year 0.985 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 129 out of 310 males with E4_PARANAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_PARANAS.

N-year risk Females Males
1 0.142% 0.283%
5 0.791% 1.52%
10 2.046% 4.214%
15 4.067% 8.631%
20 7.273% 14.569%

Relationships between endpoints

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Index endpoint: E4_PARANAS – Disorders of parathyroid gland, other and/or unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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