This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Non-neuropathic heredofamilial amyloidosis
E4_AMYL_NONNEURO
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
39 |
4. Check minimum number of eventsNone |
39 |
5. Include endpointsNone |
39 |
6. Filter based on genotype QC (FinnGen only) |
37 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E85
Name in latin
Amyloidosis (heredo)familialis non neuropathica
Similar endpoints
↥List of similar endpoints to
Non-neuropathic heredofamilial amyloidosis
based on the number of shared cases.
Similar with more cases:
- Amyloidosis
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 340 | 178 | 158 |
| Only index persons | 227 | 120 | 107 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.01 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 63.80 | 64.07 | 63.99 |
| Only index persons | 62.36 | 60.71 | 64.20 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 37 | 22 | 15 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 56.95 | 49.93 | 67.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint E4_AMYL_NONNEURO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMYL_NONNEURO | 8.55 [5.5, 13.29] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.112 |
During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 152 females with E4_AMYL_NONNEURO died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have E4_AMYL_NONNEURO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.804% | No data |
| 5 | 4.461% | No data |
| 10 | 10.862% | No data |
| 15 | 19.995% | No data |
| 20 | 33.185% | No data |
Relationships between endpoints
↥Index endpoint: E4_AMYL_NONNEURO – Non-neuropathic heredofamilial amyloidosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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