amyloidosis: A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
503 |
4. Check minimum number of eventsNone |
503 |
5. Include endpointsNone |
503 |
6. Filter based on genotype QC (FinnGen only) |
492 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Amyloidosis, other/unspecified
based on the number of shared cases.
Similar with more cases:
- Amyloidosis
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5263 | 2849 | 2321 |
| Only index persons | 3048 | 1579 | 1469 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.08 | 0.06 |
| Only index persons | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 67.37 | 66.72 | 68.27 |
| Only index persons | 68.90 | 67.88 | 69.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 492 | 243 | 249 |
| Unadjusted period prevalence (%) | 0.11 | 0.10 | 0.13 |
| Median age at first event (years) | 66.57 | 62.32 | 70.71 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_AMYLNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMYLNAS | 5.481 [4.42, 6.8] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.681 |
During the follow-up period (1.1.1998 — 31.12.2019), 696 out of 1370 females with E4_AMYLNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMYLNAS | 4.06 [3.17, 5.2] | < 0.001 |
| Birth year | 0.985 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 668 out of 1241 males with E4_AMYLNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_AMYLNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.4% | 0.707% |
| 5 | 3.508% | 4.19% |
| 10 | 8.544% | 10.612% |
| 15 | 15.418% | 19.136% |
| 20 | 27.346% | 30.589% |
Relationships between endpoints
↥Index endpoint: E4_AMYLNAS – Amyloidosis, other/unspecified
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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