amyloidosis: A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
98 |
4. Check minimum number of eventsNone |
98 |
5. Include endpointsNone |
98 |
6. Filter based on genotype QC (FinnGen only) |
96 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E85
Name in latin
Amyloidosis systemica secundaria
Similar endpoints
↥List of similar endpoints to
Secondary systemic amyloidosis
based on the number of shared cases.
Similar with more cases:
- Amyloidosis
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1290 | 873 | 392 |
| Only index persons | 670 | 472 | 198 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 66.38 | 66.66 | 65.34 |
| Only index persons | 64.41 | 64.70 | 63.72 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 96 | 60 | 36 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 61.68 | 59.52 | 65.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_AMYL_SCNDSYST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMYL_SCNDSYST | 7.651 [6.33, 9.25] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.982 |
During the follow-up period (1.1.1998 — 31.12.2019), 408 out of 583 females with E4_AMYL_SCNDSYST died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_AMYL_SCNDSYST | 6.313 [4.57, 8.71] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.024 |
During the follow-up period (1.1.1998 — 31.12.2019), 207 out of 270 males with E4_AMYL_SCNDSYST died.
Mortality risk
Mortality risk for people of age
years, who have E4_AMYL_SCNDSYST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.594% | 1.358% |
| 5 | 4.313% | 7.536% |
| 10 | 11.776% | 18.552% |
| 15 | 22.493% | 31.996% |
| 20 | 36.046% | 49.217% |
Relationships between endpoints
↥Index endpoint: E4_AMYL_SCNDSYST – Secondary systemic amyloidosis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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