≡ Risteys
FG R11 + FR

Documentation Changelog GitHub Contact & Feedback

Adrenocortical insufficiency

DOID EFO Endpoint Browser PheWeb

E4_ADDISON

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E27.1, E27.2, E27.3#, E27.4
  • Hospital discharge: ICD-9 — 2554
  • Hospital discharge: ICD-8 — 2551
  • Cause of death: ICD-10 — E27.1, E27.2, E27.3#, E27.4
  • Cause of death: ICD-9 — 2554
  • Cause of death: ICD-8 — 2551
  • KELA reimbursements: KELA codes — 105

3 out of 7 registries used, show all original rules.

1155

4. Check minimum number of events

None

1155

5. Include endpoints

None

1155

6. Filter based on genotype QC (FinnGen only)

1116

Control definitions (FinnGen only)

Control exclude E4_ENDOGLAND

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7708 4664 2983
Only index persons 6408 3987 2421
Unadjusted period prevalence (%)
Whole population 0.11 0.13 0.08
Only index persons 0.13 0.15 0.09
Median age at first event (years)
Whole population 52.50 53.53 50.87
Only index persons 52.56 53.14 51.61

-FinnGen-

Key figures

All Female Male
Number of individuals 1116 738 378
Unadjusted period prevalence (%) 0.26 0.29 0.19
Median age at first event (years) 54.16 51.35 59.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

↥

Association

Association between endpoint E4_ADDISON and mortality.

Females

Parameter HR [95% CI] p-value
E4_ADDISON 3.11 [2.63, 3.68] < 0.001
Birth year 0.992 [0.98, 1.0] 0.064

During the follow-up period (1.1.1998 — 31.12.2019), 772 out of 3174 females with E4_ADDISON died.

Males

Parameter HR [95% CI] p-value
E4_ADDISON 3.382 [2.67, 4.29] < 0.001
Birth year 0.99 [0.98, 1.0] 0.035

During the follow-up period (1.1.1998 — 31.12.2019), 628 out of 2061 males with E4_ADDISON died.

Mortality risk

Mortality risk for people of age

years, who have E4_ADDISON.

N-year risk Females Males
1 0.367% 0.675%
5 1.877% 4.233%
10 4.403% 9.797%
15 7.805% 19.147%
20 13.146% 30.999%

Relationships between endpoints

↥

Index endpoint: E4_ADDISON – Adrenocortical insufficiency

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data