No definition available.
Drug-induced adrenocortical insufficiency
DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
527 |
4. Check minimum number of eventsNone |
527 |
5. Include endpointsNone |
527 |
6. Filter based on genotype QC (FinnGen only) |
509 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced adrenocortical insufficiency
based on the number of shared cases.
Similar with more cases:
- Adrenocortical insufficiency
- Other disorders of adrenal gland
- Exclusions for E4_PCOS_BROAD
- Disorders of other endocrine glands
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2471 | 1595 | 868 |
| Only index persons | 2275 | 1493 | 782 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.05 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 57.01 | 57.43 | 56.23 |
| Only index persons | 58.04 | 57.88 | 58.36 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 509 | 351 | 158 |
| Unadjusted period prevalence (%) | 0.12 | 0.14 | 0.08 |
| Median age at first event (years) | 58.01 | 55.37 | 63.88 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY | 3.3 [2.56, 4.25] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.61 |
During the follow-up period (1.1.1998 — 31.12.2019), 228 out of 1280 females with DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY | 3.434 [2.34, 5.04] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 676 males with DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.391% | 0.637% |
| 5 | 2.02% | 4.028% |
| 10 | 5.264% | 9.927% |
| 15 | 9.781% | 17.921% |
| 20 | 17.281% | 28.456% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_ADRENOCORTICAL_INSUFFICIENCY – Drug-induced adrenocortical insufficiency
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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