This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Drug-induced aplastic anaemia
DRUGADVERS_APLAST_ANAEM
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
52 |
4. Check minimum number of eventsNone |
52 |
5. Include endpointsNone |
52 |
6. Filter based on genotype QC (FinnGen only) |
47 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Drug-induced aplastic anaemia
based on the number of shared cases.
Similar with more cases:
- Other and unspecified aplastic anaemias
- Aplastic and other anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 549 | 296 | 245 |
| Only index persons | 425 | 235 | 190 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 69.55 | 71.11 | 67.73 |
| Only index persons | 68.94 | 70.57 | 66.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 47 | 23 | 24 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 62.85 | 58.14 | 67.37 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_APLAST_ANAEM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_APLAST_ANAEM | 4.979 [2.92, 8.49] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.247 |
During the follow-up period (1.1.1998 — 31.12.2019), 149 out of 248 females with DRUGADVERS_APLAST_ANAEM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_APLAST_ANAEM | 6.784 [3.45, 13.35] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 138 out of 209 males with DRUGADVERS_APLAST_ANAEM died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_APLAST_ANAEM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.537% | 0.922% |
| 5 | 3.103% | 7.005% |
| 10 | 7.649% | 16.357% |
| 15 | 14.183% | 29.634% |
| 20 | 22.687% | 44.419% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_APLAST_ANAEM – Drug-induced aplastic anaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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