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Other and unspecified aplastic anaemias

DOID EFO Endpoint Browser PheWeb

D3_OTHERAPLASTICANAEMIA

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D61
  • Hospital discharge: ICD-9 — 2848
  • Hospital discharge: ICD-8 — 284
  • Hospital discharge: excluded ICD-9 — 2848C
  • Hospital discharge: excluded ICD-8 — 28404
  • Cause of death: ICD-10 — D61
  • Cause of death: ICD-9 — 2848
  • Cause of death: ICD-8 — 284
  • Cause of death: excluded ICD-9 — 2848C
  • Cause of death: excluded ICD-8 — 28404
  • KELA reimbursements: KELA codes — 122

3 out of 7 registries used, show all original rules.

374

4. Check minimum number of events

None

374

5. Include endpoints

None

374

6. Filter based on genotype QC (FinnGen only)

346

Control definitions (FinnGen only)

Control exclude D3_APLASTICANDOTHANAEMIA

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D60-D64
Name in latin Aliae anaemia aplasticae

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4109 2037 1985
Only index persons 2722 1371 1351
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.06
Only index persons 0.05 0.05 0.05
Median age at first event (years)
Whole population 64.32 65.00 63.49
Only index persons 61.52 61.81 61.22

-FinnGen-

Key figures

All Female Male
Number of individuals 346 172 174
Unadjusted period prevalence (%) 0.08 0.07 0.09
Median age at first event (years) 58.69 51.66 65.65

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint D3_OTHERAPLASTICANAEMIA and mortality.

Females

Parameter HR [95% CI] p-value
D3_OTHERAPLASTICANAEMIA 4.14 [3.24, 5.29] < 0.001
Birth year 0.995 [0.99, 1.0] 0.266

During the follow-up period (1.1.1998 — 31.12.2019), 646 out of 1166 females with D3_OTHERAPLASTICANAEMIA died.

Males

Parameter HR [95% CI] p-value
D3_OTHERAPLASTICANAEMIA 3.95 [3.02, 5.16] < 0.001
Birth year 0.991 [0.98, 1.0] 0.051

During the follow-up period (1.1.1998 — 31.12.2019), 660 out of 1238 males with D3_OTHERAPLASTICANAEMIA died.

Mortality risk

Mortality risk for people of age

years, who have D3_OTHERAPLASTICANAEMIA.

N-year risk Females Males
1 0.339% 0.703%
5 2.533% 4.934%
10 5.664% 12.691%
15 10.663% 22.855%
20 18.979% 36.188%

Relationships between endpoints

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Index endpoint: D3_OTHERAPLASTICANAEMIA – Other and unspecified aplastic anaemias

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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