neovascular glaucoma: Neovascular glaucoma is the most common type of secondary glaucoma, usually caused by diabetic retinopathy, central retinal vein occlusion and carotid artery obstruction but sometimes by trauma, uvietis or ocular tumors, and characterized by severe eye pain, synechial angle glaucoma, high intraocular pressure and leading to loss of vision.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1412 |
4. Check minimum number of eventsNone |
1412 |
5. Include endpointsNone |
1412 |
6. Filter based on genotype QC (FinnGen only) |
1353 |
Control definitions (FinnGen only)
Control exclude
DM_RETINOPATHY
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H40
Name in latin
Glaucoma [secundarium] post aliam morbositatem oculi
Similar endpoints
↥List of similar endpoints to
Neovascular glaucoma
based on the number of shared cases.
Similar with more cases:
- Glaucoma secondary to other eye disorders
- Glaucoma
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 13210 | 6427 | 6667 |
| Only index persons | 11515 | 5648 | 5867 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.18 | 0.18 | 0.19 |
| Only index persons | 0.22 | 0.21 | 0.22 |
| Median age at first event (years) | |||
| Whole population | 69.00 | 71.81 | 66.26 |
| Only index persons | 67.58 | 70.30 | 64.96 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1353 | 623 | 730 |
| Unadjusted period prevalence (%) | 0.31 | 0.24 | 0.37 |
| Median age at first event (years) | 63.16 | 59.41 | 66.36 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint DM_NEOVASCULAR_GLAUCOMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DM_NEOVASCULAR_GLAUCOMA | 1.487 [1.34, 1.65] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.06 |
During the follow-up period (1.1.1998 — 31.12.2019), 2304 out of 5718 females with DM_NEOVASCULAR_GLAUCOMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DM_NEOVASCULAR_GLAUCOMA | 1.544 [1.37, 1.74] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 2217 out of 5865 males with DM_NEOVASCULAR_GLAUCOMA died.
Mortality risk
Mortality risk for people of age
years, who have DM_NEOVASCULAR_GLAUCOMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.122% | 0.325% |
| 5 | 0.783% | 1.768% |
| 10 | 1.893% | 4.415% |
| 15 | 3.686% | 8.414% |
| 20 | 6.273% | 14.365% |
Relationships between endpoints
↥Index endpoint: DM_NEOVASCULAR_GLAUCOMA – Neovascular glaucoma
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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