This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Hypergammalglobulinemia, unspecified
D3_HYPERGAMMAGLONAS
immune system disease: A disorder resulting from an abnormality in the immune system.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
30 |
4. Check minimum number of eventsNone |
30 |
5. Include endpointsNone |
30 |
6. Filter based on genotype QC (FinnGen only) |
30 |
Control definitions (FinnGen only)
Control exclude
D3_IMMUNEMECHANISM
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D89
Name in latin
Hypergammaglobulinaemia non specificata
Similar endpoints
↥List of similar endpoints to
Hypergammalglobulinemia, unspecified
based on the number of shared cases.
Similar with more cases:
- Other disorders involving the immune mechanism, not elsewhere classified
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 225 | 103 | 120 |
| Only index persons | 169 | 84 | 85 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.00 | 0.00 | 0.00 |
| Only index persons | 0.00 | 0.00 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 66.41 | 65.47 | 67.14 |
| Only index persons | 64.83 | 64.44 | 65.22 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 30 | 12 | 18 |
| Unadjusted period prevalence (%) | 0.01 | 0.00 | 0.01 |
| Median age at first event (years) | 61.26 | 53.04 | 66.75 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint D3_HYPERGAMMAGLONAS and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HYPERGAMMAGLONAS | 2.562 [1.51, 4.34] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 57 out of 109 males with D3_HYPERGAMMAGLONAS died.
Mortality risk
Mortality risk for people of age
years, who have D3_HYPERGAMMAGLONAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.467% |
| 5 | No data | 2.937% |
| 10 | No data | 7.793% |
| 15 | No data | 14.578% |
| 20 | No data | 23.334% |
Relationships between endpoints
↥Index endpoint: D3_HYPERGAMMAGLONAS – Hypergammalglobulinemia, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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