obsolete_common variable immunodeficiency: ['A hypogammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. Patients with common variable immunodeficiency have marked reduction in serum levels of both immunoglobulin G (IgG) and immunoglobulin A (IgA); about half of these patients also have reduced immunoglobulin M (IgM).', 'A primary immunodeficiency characterized by low levels or absence of all the immunoglobulin classes and lack of B-lymphocytes or plasma cells. It results in recurrent bacterial infections. Complications include autoimmune phenomena and cancer development.', 'Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.']
Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
D3_CVID_BCELL
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
79 |
4. Check minimum number of eventsNone |
79 |
5. Include endpointsNone |
79 |
6. Filter based on genotype QC (FinnGen only) |
77 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function based on the number of shared cases.
Similar with more cases:
- Common variable immunodeficiency
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 312 | 164 | 146 |
Only index persons | 287 | 154 | 133 |
Unadjusted period prevalence (%) | |||
Whole population | 0.00 | 0.00 | 0.00 |
Only index persons | 0.01 | 0.01 | 0.01 |
Median age at first event (years) | |||
Whole population | 49.79 | 49.97 | 49.50 |
Only index persons | 47.93 | 48.90 | 46.80 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 77 | 47 | 30 |
Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
Median age at first event (years) | 46.82 | 47.68 | 45.46 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_CVID_BCELL and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have D3_CVID_BCELL.N-year risk | Females | Males |
---|---|---|
1 | No data | No data |
5 | No data | No data |
10 | No data | No data |
15 | No data | No data |
20 | No data | No data |
Relationships between endpoints
↥Index endpoint: D3_CVID_BCELL – Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
GWS hits: -