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Other and unspecified iron deficiency

DOID EFO Endpoint Browser PheWeb

D3_ANAEMIA_IRONDEF_NAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D50
  • Hospital discharge: ICD-9 — 280
  • Hospital discharge: ICD-8 — 280
  • Hospital discharge: excluded ICD-10 — D50.0
  • Hospital discharge: excluded ICD-9 — 2800
  • Hospital discharge: excluded ICD-8 — 2800
  • Cause of death: ICD-10 — D50
  • Cause of death: ICD-9 — 280
  • Cause of death: ICD-8 — 280
  • Cause of death: excluded ICD-10 — D50.0
  • Cause of death: excluded ICD-9 — 2800
  • Cause of death: excluded ICD-8 — 2800

2 out of 7 registries used, show all original rules.

13411

4. Check minimum number of events

None

13411

5. Include endpoints

None

13411

6. Filter based on genotype QC (FinnGen only)

12886

Control definitions (FinnGen only)

Control exclude D3_NUTRIANAEMIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D50-D53
Name in latin Anaemia sideropenica

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 120397 77322 41904
Only index persons 101000 67254 33746
Unadjusted period prevalence (%)
Whole population 1.84 2.21 1.17
Only index persons 2.08 2.47 1.29
Median age at first event (years)
Whole population 67.52 66.74 68.98
Only index persons 65.00 63.34 68.31

-FinnGen-

Key figures

All Female Male
Number of individuals 12886 7897 4989
Unadjusted period prevalence (%) 2.87 3.10 2.51
Median age at first event (years) 61.73 56.25 70.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint D3_ANAEMIA_IRONDEF_NAS and mortality.

Females

Parameter HR [95% CI] p-value
D3_ANAEMIA_IRONDEF_NAS 2.055 [1.85, 2.28] < 0.001
Birth year 0.994 [0.99, 1.0] 0.123

During the follow-up period (1.1.1998 — 31.12.2019), 19192 out of 58194 females with D3_ANAEMIA_IRONDEF_NAS died.

Males

Parameter HR [95% CI] p-value
D3_ANAEMIA_IRONDEF_NAS 2.512 [2.22, 2.85] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 13751 out of 31515 males with D3_ANAEMIA_IRONDEF_NAS died.

Mortality risk

Mortality risk for people of age

years, who have D3_ANAEMIA_IRONDEF_NAS.

N-year risk Females Males
1 0.207% 0.46%
5 1.132% 2.819%
10 2.725% 7.102%
15 5.221% 12.631%
20 9.086% 21.233%

Relationships between endpoints

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Index endpoint: D3_ANAEMIA_IRONDEF_NAS – Other and unspecified iron deficiency

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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