hemolytic anemia: Hemolytic anemia that is not mediated by immune mechanisms.
Iron deficiency anaemia secondary to blood loss (chronic)
DOID EFO Endpoint Browser PheWeb
D3_ANAEMIA_IRONDEF_BLOODLOSS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
6176 |
4. Check minimum number of eventsNone |
6176 |
5. Include endpointsNone |
6176 |
6. Filter based on genotype QC (FinnGen only) |
5949 |
Control definitions (FinnGen only)
Control exclude
D3_NUTRIANAEMIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D50
Name in latin
Anaemia posthaemorrhagica
Similar endpoints
↥List of similar endpoints to
Iron deficiency anaemia secondary to blood loss (chronic)
based on the number of shared cases.
Similar with more cases:
- Iron deficiency anaemia
- Nutritional anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 68341 | 42710 | 24899 |
| Only index persons | 52427 | 33975 | 18452 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.03 | 1.22 | 0.70 |
| Only index persons | 1.06 | 1.25 | 0.70 |
| Median age at first event (years) | |||
| Whole population | 60.11 | 55.68 | 67.57 |
| Only index persons | 56.38 | 50.57 | 67.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 5949 | 3454 | 2495 |
| Unadjusted period prevalence (%) | 1.31 | 1.36 | 1.25 |
| Median age at first event (years) | 56.35 | 46.73 | 69.67 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint D3_ANAEMIA_IRONDEF_BLOODLOSS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ANAEMIA_IRONDEF_BLOODLOSS | 2.391 [2.13, 2.69] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.162 |
During the follow-up period (1.1.1998 — 31.12.2019), 8628 out of 20032 females with D3_ANAEMIA_IRONDEF_BLOODLOSS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ANAEMIA_IRONDEF_BLOODLOSS | 3.277 [2.84, 3.78] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 7800 out of 14404 males with D3_ANAEMIA_IRONDEF_BLOODLOSS died.
Mortality risk
Mortality risk for people of age
years, who have D3_ANAEMIA_IRONDEF_BLOODLOSS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.264% | 0.505% |
| 5 | 1.337% | 3.356% |
| 10 | 3.514% | 8.571% |
| 15 | 6.532% | 16.065% |
| 20 | 10.58% | 26.142% |
Relationships between endpoints
↥Index endpoint: D3_ANAEMIA_IRONDEF_BLOODLOSS – Iron deficiency anaemia secondary to blood loss (chronic)
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data