chronic obstructive pulmonary disease: A chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersPre-conditions: EVENT_AGE<65 Registry filters:
2 out of 7 registries used, show all original rules. |
8555 |
4. Check minimum number of eventsNone |
8555 |
5. Include endpointsNone |
8555 |
6. Filter based on genotype QC (FinnGen only) |
8266 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to Early onset COPD based on the number of shared cases.
Similar with more cases:
- Early onset COPD
- Other chronic obstructive pulmonary disease
- COPD, early/later onset
- COPD
- Other chronic obstructive pulmonary disease , including avohilmo
Similar with less cases:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 81002 | 25780 | 53894 |
Only index persons | 60251 | 21696 | 38555 |
Unadjusted period prevalence (%) | |||
Whole population | 1.26 | 0.74 | 1.51 |
Only index persons | 1.23 | 0.80 | 1.47 |
Median age at first event (years) | |||
Whole population | 57.10 | 56.55 | 57.32 |
Only index persons | 56.50 | 56.17 | 56.69 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 8266 | 3066 | 5200 |
Unadjusted period prevalence (%) | 2.09 | 1.20 | 2.61 |
Median age at first event (years) | 57.20 | 55.70 | 58.09 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint COPD_EARLY and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
COPD_EARLY | 5.788 [5.33, 6.28] | < 0.001 |
Birth year | 0.99 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 5790 out of 19608 females with COPD_EARLY died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
COPD_EARLY | 4.076 [3.78, 4.4] | < 0.001 |
Birth year | 0.988 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 14125 out of 35925 males with COPD_EARLY died.
Mortality risk
Mortality risk for people of age
years, who have COPD_EARLY.N-year risk | Females | Males |
---|---|---|
1 | 0.467% | 0.687% |
5 | 2.872% | 4.076% |
10 | 6.558% | 10.345% |
15 | 12.484% | 19.555% |
20 | 21.139% | 31.398% |
Relationships between endpoints
↥Index endpoint: COPD_EARLY – Early onset COPD
GWS hits: 6