No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
550 |
4. Check minimum number of eventsNone |
550 |
5. Include endpointsNone |
550 |
6. Filter based on genotype QC (FinnGen only) |
537 |
Control definitions (FinnGen only)
Control exclude
DM_COMORB
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Charcot foot
based on the number of shared cases.
Similar with more cases:
- Arthropathies in other diseases classified elsewhere
- Polyarthropathies
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2963 | 1049 | 1905 |
| Only index persons | 2733 | 981 | 1752 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.03 | 0.05 |
| Only index persons | 0.06 | 0.04 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 59.21 | 58.96 | 59.31 |
| Only index persons | 59.26 | 59.05 | 59.37 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 537 | 205 | 332 |
| Unadjusted period prevalence (%) | 0.13 | 0.08 | 0.17 |
| Median age at first event (years) | 57.25 | 54.42 | 59.00 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CHARCOT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHARCOT | 4.271 [3.4, 5.36] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.632 |
During the follow-up period (1.1.1998 — 31.12.2019), 315 out of 967 females with CHARCOT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHARCOT | 3.542 [3.05, 4.12] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 666 out of 1747 males with CHARCOT died.
Mortality risk
Mortality risk for people of age
years, who have CHARCOT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.451% | 0.669% |
| 5 | 2.692% | 3.937% |
| 10 | 6.796% | 9.969% |
| 15 | 12.892% | 18.049% |
| 20 | 21.804% | 30.416% |
Relationships between endpoints
↥Index endpoint: CHARCOT – Charcot foot
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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