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Leukaemia of unspecified cell type

DOID EFO Endpoint Browser

CD2_LEUKAEMIA_NAS

leukemia: A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes, and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measured in weeks or months, while that of chronic leukemias is more often measured in months or years.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C95
  • Hospital discharge: ICD-9 — 20[7-8]
  • Hospital discharge: ICD-8 — 207
  • Hospital discharge: excluded ICD-9 — 207[0-8]
  • Hospital discharge: excluded ICD-8 — 207[0-2]
  • Cause of death: ICD-10 — C95
  • Cause of death: ICD-9 — 20[7-8]
  • Cause of death: ICD-8 — 207
  • Cause of death: excluded ICD-9 — 207[0-8]
  • Cause of death: excluded ICD-8 — 207[0-2]

2 out of 7 registries used, show all original rules.

298

4. Check minimum number of events

None

298

5. Include endpoints

None

298

6. Filter based on genotype QC (FinnGen only)

268

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF8
Parent code in ICD-10 C81-C96
Name in latin Leuc(h)aemiae typo cellulari non specificato

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 268 122 146
Unadjusted period prevalence (%) 0.06 0.05 0.07
Median age at first event (years) 62.76 57.28 67.33

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: CD2_LEUKAEMIA_NAS – Leukaemia of unspecified cell type

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).