No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Control conditions
not HLP_C3_AML
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Acute myeloid leukaemia
based on the number of shared cases.
Similar with more cases:
- Acute myeloid leukaemia
- Acute myeloid leukaemia
- Any event in cancer register
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6001 | 2847 | 2999 |
| Only index persons | 2621 | 1336 | 1285 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.05 | 0.05 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 65.21 | 64.86 | 65.46 |
| Only index persons | 66.44 | 65.75 | 67.16 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 321 | 130 | 191 |
| Unadjusted period prevalence (%) | 0.08 | 0.05 | 0.10 |
| Median age at first event (years) | 66.10 | 59.15 | 70.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_AML_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_AML_EXALLC | 19.259 [12.11, 30.63] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.199 |
During the follow-up period (1.1.1998 — 31.12.2019), 929 out of 1367 females with C3_AML_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_AML_EXALLC | 15.868 [9.54, 26.39] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 1005 out of 1364 males with C3_AML_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_AML_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.303% | 3.557% |
| 5 | 8.883% | 19.421% |
| 10 | 22.235% | 38.98% |
| 15 | 39.061% | 60.731% |
| 20 | 58.437% | 80.863% |
Relationships between endpoints
↥Index endpoint: C3_AML_EXALLC – Acute myeloid leukaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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