Benign neoplasm: salivary glands, exclude unknown (D119)

CD2_BENIGN_SALIVARY_KNOWN

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

3024

4. Check minimum number of events

None

3024

5. Include endpoints

None

3024

6. Filter based on genotype QC (FinnGen only)

2921

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19916 10324 9492
Only index persons 18679 9842 8837
Unadjusted period prevalence (%)
Whole population 0.28 0.30 0.27
Only index persons 0.35 0.36 0.34
Median age at first event (years)
Whole population 60.67 60.79 60.55
Only index persons 59.98 60.13 59.82

-FinnGen-

Key figures

All Female Male
Number of individuals 2921 1499 1422
Unadjusted period prevalence (%) 0.65 0.59 0.71
Median age at first event (years) 60.04 57.27 62.95

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_SALIVARY_KNOWN and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_SALIVARY_KNOWN 1.245 [1.13, 1.37] < 0.001
Birth year 0.995 [0.99, 1.0] 0.204

During the follow-up period (1.1.1998 — 31.12.2019), 1747 out of 9004 females with CD2_BENIGN_SALIVARY_KNOWN died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_SALIVARY_KNOWN 1.447 [1.31, 1.6] < 0.001
Birth year 0.988 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 2033 out of 8254 males with CD2_BENIGN_SALIVARY_KNOWN died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_SALIVARY_KNOWN.

N-year risk Females Males
1 0.106% 0.249%
5 0.728% 1.388%
10 1.937% 4.022%
15 3.849% 7.767%
20 6.407% 12.739%

Relationships between endpoints

Index endpoint: CD2_BENIGN_SALIVARY_KNOWN – Benign neoplasm: salivary glands, exclude unknown (D119)

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data