Benign neoplasm: Parotid gland

CD2_BENIGN_PAROTID

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D11.0&
  • Cause of death: ICD-10 D11.0&

2 out of 7 registries used, show all original rules.

2701

4. Check minimum number of events

None

2701

5. Include endpoints

None

2701

6. Filter based on genotype QC (FinnGen only)

2606

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D11
Name in latin Neoplasma benignum glandulae parotideae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 17545 8978 8482
Only index persons 16470 8568 7902
Unadjusted period prevalence (%)
Whole population 0.25 0.26 0.24
Only index persons 0.31 0.31 0.30
Median age at first event (years)
Whole population 60.81 60.80 60.83
Only index persons 60.12 60.11 60.12

-FinnGen-

Key figures

All Female Male
Number of individuals 2606 1320 1286
Unadjusted period prevalence (%) 0.58 0.52 0.65
Median age at first event (years) 60.09 57.20 63.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_PAROTID and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_PAROTID 1.19 [1.08, 1.32] < 0.001
Birth year 0.998 [0.99, 1.01] 0.646

During the follow-up period (1.1.1998 — 31.12.2019), 1511 out of 7825 females with CD2_BENIGN_PAROTID died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_PAROTID 1.421 [1.28, 1.58] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1822 out of 7379 males with CD2_BENIGN_PAROTID died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_PAROTID.

N-year risk Females Males
1 0.135% 0.232%
5 0.745% 1.402%
10 1.798% 3.64%
15 3.695% 6.904%
20 6.618% 11.678%

Relationships between endpoints

Index endpoint: CD2_BENIGN_PAROTID – Benign neoplasm: Parotid gland

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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