obsolete_meningioma: ['A tumor of meningothelial cells that are manifested in the central nervous system and arise from the arachnoid "cap" cells of the arachnoid villi in the meninges.']
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3297 |
4. Check minimum number of eventsNone |
3297 |
5. Include endpoints |
3394 |
6. Filter based on genotype QC (FinnGen only) |
3283 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D10-D36
Name in latin
Neoplasma benignum meningum
Similar endpoints
↥List of similar endpoints to
Benign neoplasm of meninges
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm of meninges
- Benign neoplasms
- Benign neoplasms
- Neoplasms
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 24691 | 18210 | 6316 |
| Only index persons | 21257 | 16014 | 5243 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.43 | 0.52 | 0.18 |
| Only index persons | 0.49 | 0.59 | 0.20 |
| Median age at first event (years) | |||
| Whole population | 64.58 | 64.77 | 64.01 |
| Only index persons | 63.92 | 64.05 | 63.52 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3283 | 2460 | 823 |
| Unadjusted period prevalence (%) | 0.83 | 0.97 | 0.41 |
| Median age at first event (years) | 62.29 | 61.15 | 65.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_MENINGES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MENINGES | 1.507 [1.37, 1.65] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.453 |
During the follow-up period (1.1.1998 — 31.12.2019), 3477 out of 13400 females with CD2_BENIGN_MENINGES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_MENINGES | 1.823 [1.6, 2.08] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 1506 out of 4504 males with CD2_BENIGN_MENINGES died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_MENINGES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.163% | 0.304% |
| 5 | 0.929% | 2.125% |
| 10 | 2.473% | 4.988% |
| 15 | 4.748% | 9.416% |
| 20 | 8.5% | 15.69% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_MENINGES – Benign neoplasm of meninges
GWS hits: 6
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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