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Benign neoplasm: Cerebral meninges

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_MENINGES_CEREBRAL

colonic neoplasm: A benign or malignant neoplasm that affects the colon. Representative examples of benign neoplasms include lipoma and leiomyoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and sarcoma. Colonic adenomas always exhibit epithelial dysplasia and are considered premalignant neoplasms.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D32.0
  • Hospital discharge: ICD-9 — 2252
  • Hospital discharge: ICD-8 — 2252
  • Cause of death: ICD-10 — D32.0
  • Cause of death: ICD-9 — 2252
  • Cause of death: ICD-8 — 2252

2 out of 7 registries used, show all original rules.

3050

4. Check minimum number of events

None

3050

5. Include endpoints

None

3050

6. Filter based on genotype QC (FinnGen only)

2952

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D32
Name in latin Neoplasma benignum meningum cranialium

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 21809 16225 5444
Only index persons 18958 14404 4554
Unadjusted period prevalence (%)
Whole population 0.38 0.46 0.15
Only index persons 0.44 0.53 0.17
Median age at first event (years)
Whole population 64.57 64.55 64.62
Only index persons 64.01 63.93 64.27

-FinnGen-

Key figures

All Female Male
Number of individuals 2952 2235 717
Unadjusted period prevalence (%) 0.75 0.88 0.36
Median age at first event (years) 62.22 61.02 65.94

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint CD2_BENIGN_MENINGES_CEREBRAL and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_MENINGES_CEREBRAL 1.557 [1.41, 1.72] < 0.001
Birth year 0.994 [0.99, 1.0] 0.127

During the follow-up period (1.1.1998 — 31.12.2019), 2938 out of 11921 females with CD2_BENIGN_MENINGES_CEREBRAL died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_MENINGES_CEREBRAL 1.748 [1.52, 2.01] < 0.001
Birth year 0.984 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 1266 out of 3849 males with CD2_BENIGN_MENINGES_CEREBRAL died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_MENINGES_CEREBRAL.

N-year risk Females Males
1 0.156% 0.314%
5 0.846% 2.025%
10 2.121% 4.629%
15 4.094% 8.658%
20 7.325% 14.584%

Relationships between endpoints

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Index endpoint: CD2_BENIGN_MENINGES_CEREBRAL – Benign neoplasm: Cerebral meninges

GWS hits: 5

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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