liver neoplasm: A benign or malignant epithelial neoplasm that affects the liver parenchyma and intrahepatic bile ducts. Representative examples of benign epithelial neoplasms include hepatocellular adenoma and intrahepatic bile duct adenoma. Representative examples of malignant epithelial neoplasms include hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
677 |
4. Check minimum number of eventsNone |
677 |
5. Include endpointsNone |
677 |
6. Filter based on genotype QC (FinnGen only) |
658 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Similar endpoints
↥List of similar endpoints to Benign neoplasm: Liver based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Liver
- Benign neoplasm: Liver/bile ducts
- Benign neoplasm: Liver/bile ducts
- Benign neoplasm of other and ill-defined parts of digestive system
- Benign neoplasm of other and ill-defined parts of digestive system
Similar with less cases:
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 3928 | 2744 | 1154 |
Only index persons | 3579 | 2565 | 1014 |
Unadjusted period prevalence (%) | |||
Whole population | 0.06 | 0.08 | 0.03 |
Only index persons | 0.08 | 0.09 | 0.04 |
Median age at first event (years) | |||
Whole population | 51.46 | 48.25 | 58.77 |
Only index persons | 50.04 | 46.94 | 57.87 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 658 | 480 | 178 |
Unadjusted period prevalence (%) | 0.16 | 0.19 | 0.09 |
Median age at first event (years) | 52.48 | 48.72 | 62.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_LIVER and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
CD2_BENIGN_LIVER | 1.688 [1.43, 2.0] | < 0.001 |
Birth year | 0.997 [0.99, 1.01] | 0.509 |
During the follow-up period (1.1.1998 — 31.12.2019), 253 out of 2095 females with CD2_BENIGN_LIVER died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
CD2_BENIGN_LIVER | 1.949 [1.56, 2.44] | < 0.001 |
Birth year | 0.991 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 245 out of 876 males with CD2_BENIGN_LIVER died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_LIVER.N-year risk | Females | Males |
---|---|---|
1 | 0.149% | 0.446% |
5 | 0.979% | 2.341% |
10 | 2.673% | 6.015% |
15 | 5.274% | 11.44% |
20 | 9.294% | 19.489% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_LIVER – Benign neoplasm: Liver
GWS hits: -