Other benign neoplasms of connective and other soft tissue

CD2_BENIGN_CONNECTIVE_SOFT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D21
  • Cause of death: ICD-10 D21

2 out of 7 registries used, show all original rules.

2838

4. Check minimum number of events

None

2838

5. Include endpoints

3653

6. Filter based on genotype QC (FinnGen only)

3520

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D10-D36
Name in latin Alia neoplasmata benigna textus connectivi sive alterius textus mollis

Similar endpoints

List of similar endpoints to Other benign neoplasms of connective and other soft tissue based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 30572 17177 13256
Only index persons 27418 15691 11727
Unadjusted period prevalence (%)
Whole population 0.44 0.49 0.37
Only index persons 0.52 0.58 0.45
Median age at first event (years)
Whole population 45.46 46.20 44.41
Only index persons 44.50 45.45 43.23

-FinnGen-

Key figures

All Female Male
Number of individuals 3520 2113 1407
Unadjusted period prevalence (%) 0.78 0.83 0.71
Median age at first event (years) 48.82 46.90 51.70

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_CONNECTIVE_SOFT and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_CONNECTIVE_SOFT 1.099 [0.98, 1.23] 0.096
Birth year 0.993 [0.99, 1.0] 0.118

During the follow-up period (1.1.1998 — 31.12.2019), 1098 out of 10832 females with CD2_BENIGN_CONNECTIVE_SOFT died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_CONNECTIVE_SOFT 1.071 [0.96, 1.19] 0.218
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 1178 out of 8587 males with CD2_BENIGN_CONNECTIVE_SOFT died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CONNECTIVE_SOFT.

N-year risk Females Males
1 0.109% 0.216%
5 0.602% 1.208%
10 1.6% 3.055%
15 3.085% 6.047%
20 5.221% 10.154%

Relationships between endpoints

Index endpoint: CD2_BENIGN_CONNECTIVE_SOFT – Other benign neoplasms of connective and other soft tissue

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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