Benign neoplasm: Connective and other soft tissue of thorax

CD2_BENIGN_CONNSOFT_THX

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D21.3&
  • Hospital discharge: ICD-9 2154
  • Cause of death: ICD-10 D21.3&
  • Cause of death: ICD-9 2154

2 out of 7 registries used, show all original rules.

136

4. Check minimum number of events

None

136

5. Include endpoints

None

136

6. Filter based on genotype QC (FinnGen only)

131

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D21
Name in latin Neoplasma benignum textus connectivi/textus mollis thoracis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1115 664 446
Only index persons 1009 608 401
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.01
Only index persons 0.02 0.02 0.02
Median age at first event (years)
Whole population 50.52 50.31 50.70
Only index persons 50.43 50.45 50.39

-FinnGen-

Key figures

All Female Male
Number of individuals 131 71 60
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 52.44 46.32 59.69

-FinRegistry-

Age distribution of first events

0102030405060708090020406080100120140160180AgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607080051015202530AgeIndividuals

-FinRegistry-

Year distribution of first events

197019901995200020052010201520202022020406080100120140160180200YearIndividuals

-FinnGen-

Year distribution of first events

1970197519801985199020002005201020152020202302468101214161820222426YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_CONNSOFT_THX and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_CONNSOFT_THX 0.906 [0.64, 1.28] 0.579
Birth year 1.0 [0.99, 1.01] 0.96

During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 492 females with CD2_BENIGN_CONNSOFT_THX died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_CONNSOFT_THX 0.943 [0.68, 1.3] 0.719
Birth year 0.984 [0.97, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 322 males with CD2_BENIGN_CONNSOFT_THX died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_CONNSOFT_THX.

N-year risk Females Males
1 0.103% 0.156%
5 0.562% 0.944%
10 1.566% 2.524%
15 2.838% 4.836%
20 5.077% 7.941%

Relationships between endpoints

Index endpoint: CD2_BENIGN_CONNSOFT_THX – Benign neoplasm: Connective and other soft tissue of thorax

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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