No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF9
Similar endpoints
↥List of similar endpoints to
Malignant neoplasm of urinary organs
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of urinary organs
- Malignant neoplasm
- Malignant neoplasm
- Any event in cancer register
- Malignant neoplasm, wide definition for exclusion
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 31711 | 12904 | 18139 |
| Only index persons | 18581 | 7938 | 10643 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.45 | 0.37 | 0.51 |
| Only index persons | 0.36 | 0.29 | 0.41 |
| Median age at first event (years) | |||
| Whole population | 67.22 | 69.04 | 65.97 |
| Only index persons | 67.55 | 69.01 | 66.47 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3318 | 1166 | 2152 |
| Unadjusted period prevalence (%) | 0.86 | 0.46 | 1.08 |
| Median age at first event (years) | 67.23 | 66.22 | 67.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_URINARY_TRACT_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_URINARY_TRACT_EXALLC | 3.146 [2.83, 3.49] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.399 |
During the follow-up period (1.1.1998 — 31.12.2019), 3814 out of 7461 females with C3_URINARY_TRACT_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_URINARY_TRACT_EXALLC | 3.34 [2.98, 3.74] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 5330 out of 10139 males with C3_URINARY_TRACT_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_URINARY_TRACT_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.222% | 0.607% |
| 5 | 1.892% | 3.389% |
| 10 | 4.511% | 8.171% |
| 15 | 8.942% | 15.283% |
| 20 | 16.136% | 24.784% |
Relationships between endpoints
↥Index endpoint: C3_URINARY_TRACT_EXALLC – Malignant neoplasm of urinary organs
GWS hits: 3
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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