No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF9
Similar endpoints
↥List of similar endpoints to
Clear cell adenocarcinoma of kidney
based on the number of shared cases.
Similar with more cases:
- Clear cell adenocarcinoma of kidney
- Malignant neoplasm of kidney, except renal pelvis
- Malignant neoplasm of kidney, except renal pelvis
- Malignant neoplasm of urinary organs
- Malignant neoplasm of urinary organs
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6437 | 2713 | 3712 |
| Only index persons | 6255 | 2645 | 3610 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.08 | 0.10 |
| Only index persons | 0.12 | 0.10 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 68.51 | 70.36 | 67.19 |
| Only index persons | 68.46 | 70.31 | 67.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1354 | 506 | 848 |
| Unadjusted period prevalence (%) | 0.34 | 0.20 | 0.43 |
| Median age at first event (years) | 67.96 | 68.33 | 67.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_KIDNEY_CLEAR_CELL_CARCINOMA_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_KIDNEY_CLEAR_CELL_CARCINOMA_EXALLC | 2.698 [2.27, 3.2] | < 0.001 |
| Birth year | 0.999 [0.99, 1.01] | 0.837 |
During the follow-up period (1.1.1998 — 31.12.2019), 784 out of 2362 females with C3_KIDNEY_CLEAR_CELL_CARCINOMA_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_KIDNEY_CLEAR_CELL_CARCINOMA_EXALLC | 3.296 [2.72, 3.99] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.014 |
During the follow-up period (1.1.1998 — 31.12.2019), 1085 out of 3148 males with C3_KIDNEY_CLEAR_CELL_CARCINOMA_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_KIDNEY_CLEAR_CELL_CARCINOMA_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.253% | 0.725% |
| 5 | 1.759% | 4.214% |
| 10 | 4.525% | 9.553% |
| 15 | 8.495% | 17.156% |
| 20 | 15.292% | 28.183% |
Relationships between endpoints
↥Index endpoint: C3_KIDNEY_CLEAR_CELL_CARCINOMA_EXALLC – Clear cell adenocarcinoma of kidney
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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