No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
625 |
4. Check minimum number of eventsNone |
625 |
5. Include endpointsNone |
625 |
6. Filter based on genotype QC (FinnGen only) |
602 |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF9
Similar endpoints
↥List of similar endpoints to
Malignant cancer of tonsil and base of tongue
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of lip, oral cavity and pharynx
- Malignant neoplasm of head and neck
- Malignant neoplasm
- Malignant neoplasm
- Any event in cancer register
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4003 | 1269 | 2643 |
| Only index persons | 2872 | 958 | 1914 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.04 | 0.07 |
| Only index persons | 0.06 | 0.04 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 62.22 | 64.11 | 61.29 |
| Only index persons | 62.15 | 63.67 | 61.39 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 602 | 172 | 430 |
| Unadjusted period prevalence (%) | 0.17 | 0.07 | 0.22 |
| Median age at first event (years) | 61.52 | 62.40 | 61.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_TONSIL_BASETONGUE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_TONSIL_BASETONGUE | 3.473 [2.74, 4.4] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.153 |
During the follow-up period (1.1.1998 — 31.12.2019), 328 out of 865 females with C3_TONSIL_BASETONGUE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_TONSIL_BASETONGUE | 4.112 [3.38, 5.01] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.03 |
During the follow-up period (1.1.1998 — 31.12.2019), 752 out of 1796 males with C3_TONSIL_BASETONGUE died.
Mortality risk
Mortality risk for people of age
years, who have C3_TONSIL_BASETONGUE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.357% | 0.859% |
| 5 | 1.981% | 5.057% |
| 10 | 4.75% | 11.826% |
| 15 | 9.154% | 21.477% |
| 20 | 16.416% | 34.134% |
Relationships between endpoints
↥Index endpoint: C3_TONSIL_BASETONGUE – Malignant cancer of tonsil and base of tongue
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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