No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF9
Similar endpoints
↥List of similar endpoints to
Malignant neoplasm of lip, oral cavity and pharynx
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of head and neck
- Malignant neoplasm
- Malignant neoplasm
- Any event in cancer register
- Malignant neoplasm, wide definition for exclusion
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 27202 | 8245 | 18279 |
| Only index persons | 15770 | 5757 | 10013 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.43 | 0.24 | 0.51 |
| Only index persons | 0.32 | 0.21 | 0.38 |
| Median age at first event (years) | |||
| Whole population | 64.24 | 67.01 | 63.06 |
| Only index persons | 64.65 | 66.31 | 63.70 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2819 | 894 | 1925 |
| Unadjusted period prevalence (%) | 0.77 | 0.35 | 0.97 |
| Median age at first event (years) | 64.80 | 63.63 | 65.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_HEAD_AND_NECK_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_HEAD_AND_NECK_EXALLC | 2.688 [2.37, 3.05] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.088 |
During the follow-up period (1.1.1998 — 31.12.2019), 2485 out of 5372 females with C3_HEAD_AND_NECK_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_HEAD_AND_NECK_EXALLC | 3.146 [2.83, 3.5] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.027 |
During the follow-up period (1.1.1998 — 31.12.2019), 5155 out of 9714 males with C3_HEAD_AND_NECK_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_HEAD_AND_NECK_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.272% | 0.502% |
| 5 | 1.463% | 3.671% |
| 10 | 3.456% | 9.067% |
| 15 | 7.189% | 17.003% |
| 20 | 12.093% | 27.723% |
Relationships between endpoints
↥Index endpoint: C3_HEAD_AND_NECK_EXALLC – Malignant neoplasm of lip, oral cavity and pharynx
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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