No definition available.
Neuroendocrine tumor and carcinoma of rectum
C3_RECTUM_NEUROENDOCRINE_EXALLC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Neuroendocrine tumor and carcinoma of rectum
based on the number of shared cases.
Similar with more cases:
- Neuroendocrine tumor and carcinoma of rectum
- Colorectal neuroendocrine tumor and carcinoma
- Colorectal neuroendocrine tumor and carcinoma
- Colorectal cancer
- Colorectal cancer
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 789 | 430 | 354 |
| Only index persons | 645 | 368 | 277 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.04 | 56.78 | 59.72 |
| Only index persons | 57.07 | 55.80 | 58.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 110 | 62 | 48 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 56.58 | 53.91 | 60.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint C3_RECTUM_NEUROENDOCRINE_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_RECTUM_NEUROENDOCRINE_EXALLC | 1.612 [1.15, 2.26] | 0.005 |
| Birth year | 0.997 [0.99, 1.01] | 0.548 |
During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 274 females with C3_RECTUM_NEUROENDOCRINE_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_RECTUM_NEUROENDOCRINE_EXALLC | 2.735 [1.86, 4.03] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 234 males with C3_RECTUM_NEUROENDOCRINE_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_RECTUM_NEUROENDOCRINE_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.184% | 0.404% |
| 5 | 1.095% | 2.849% |
| 10 | 2.627% | 7.506% |
| 15 | 4.867% | 14.175% |
| 20 | 8.576% | 22.595% |
Relationships between endpoints
↥Index endpoint: C3_RECTUM_NEUROENDOCRINE_EXALLC – Neuroendocrine tumor and carcinoma of rectum
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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