No definition available.
Colorectal neuroendocrine tumor and carcinoma
C3_COLORECTAL_NEUROENDO_EXALLC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Colorectal neuroendocrine tumor and carcinoma
based on the number of shared cases.
Similar with more cases:
- Colorectal neuroendocrine tumor and carcinoma
- Colorectal cancer
- Colorectal cancer
- Malignant neoplasm of digestive organs
- Malignant neoplasm of digestive organs
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3417 | 2011 | 1382 |
| Only index persons | 2866 | 1747 | 1119 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.04 |
| Only index persons | 0.06 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 48.88 | 46.75 | 51.92 |
| Only index persons | 46.18 | 44.73 | 48.44 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 428 | 267 | 161 |
| Unadjusted period prevalence (%) | 0.10 | 0.10 | 0.08 |
| Median age at first event (years) | 51.64 | 47.83 | 57.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint C3_COLORECTAL_NEUROENDO_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_COLORECTAL_NEUROENDO_EXALLC | 2.433 [1.92, 3.08] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.302 |
During the follow-up period (1.1.1998 — 31.12.2019), 228 out of 1180 females with C3_COLORECTAL_NEUROENDO_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_COLORECTAL_NEUROENDO_EXALLC | 2.247 [1.8, 2.8] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 236 out of 886 males with C3_COLORECTAL_NEUROENDO_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_COLORECTAL_NEUROENDO_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.219% | 0.398% |
| 5 | 1.66% | 2.659% |
| 10 | 3.799% | 6.863% |
| 15 | 7.028% | 13.068% |
| 20 | 11.931% | 21.324% |
Relationships between endpoints
↥Index endpoint: C3_COLORECTAL_NEUROENDO_EXALLC – Colorectal neuroendocrine tumor and carcinoma
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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