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Malignant neoplasm of pancreas

Endpoint Browser PheWeb

C3_PANCREAS_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C25
  • Cause of death: ICD-9 — 157
  • Cause of death: ICD-8 — 157
  • Cancer registry: Topography ICD-O-3 — C25
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 32784 15808 16068
Only index persons 14587 7464 7123
Unadjusted period prevalence (%)
Whole population 0.46 0.45 0.45
Only index persons 0.27 0.27 0.27
Median age at first event (years)
Whole population 70.92 73.10 68.93
Only index persons 72.88 74.74 70.92

-FinnGen-

Key figures

All Female Male
Number of individuals 1992 773 1219
Unadjusted period prevalence (%) 0.49 0.30 0.61
Median age at first event (years) 70.88 70.65 71.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_PANCREAS_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_PANCREAS_EXALLC 35.382 [22.94, 54.58] < 0.001
Birth year 0.994 [0.99, 1.0] 0.153

During the follow-up period (1.1.1998 — 31.12.2019), 7322 out of 8191 females with C3_PANCREAS_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_PANCREAS_EXALLC 29.63 [18.96, 46.3] < 0.001
Birth year 0.985 [0.98, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 6846 out of 7633 males with C3_PANCREAS_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_PANCREAS_EXALLC.

N-year risk Females Males
1 2.592% 4.637%
5 15.327% 26.277%
10 33.502% 52.275%
15 53.454% 76.551%
20 74.866% 90.555%

Relationships between endpoints

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Index endpoint: C3_PANCREAS_EXALLC – Malignant neoplasm of pancreas

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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