No definition available.
Adenocarcinoma and ductal carcinoma of pancreas
C3_PANCREAS_ADENO_DUCTAL_EXALLC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
First used in FinnGen datafreeze
DF9
Similar endpoints
↥List of similar endpoints to
Adenocarcinoma and ductal carcinoma of pancreas
based on the number of shared cases.
Similar with more cases:
- Adenocarcinoma and ductal carcinoma of pancreas
- Malignant neoplasm of pancreas
- Malignant neoplasm of pancreas
- Malignant neoplasm of digestive organs
- Malignant neoplasm of digestive organs
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 15401 | 7090 | 7881 |
| Only index persons | 6685 | 3243 | 3442 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.22 | 0.20 | 0.22 |
| Only index persons | 0.13 | 0.12 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 68.08 | 69.63 | 66.81 |
| Only index persons | 70.03 | 71.21 | 68.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1033 | 432 | 601 |
| Unadjusted period prevalence (%) | 0.25 | 0.17 | 0.30 |
| Median age at first event (years) | 70.12 | 69.83 | 70.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_PANCREAS_ADENO_DUCTAL_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_PANCREAS_ADENO_DUCTAL_EXALLC | 46.391 [30.15, 71.39] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.574 |
During the follow-up period (1.1.1998 — 31.12.2019), 3336 out of 3743 females with C3_PANCREAS_ADENO_DUCTAL_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_PANCREAS_ADENO_DUCTAL_EXALLC | 31.563 [20.39, 48.87] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 3474 out of 3886 males with C3_PANCREAS_ADENO_DUCTAL_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_PANCREAS_ADENO_DUCTAL_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 3.919% | 6.144% |
| 5 | 25.718% | 29.155% |
| 10 | 48.659% | 58.411% |
| 15 | 73.369% | 82.608% |
| 20 | 90.537% | 94.932% |
Relationships between endpoints
↥Index endpoint: C3_PANCREAS_ADENO_DUCTAL_EXALLC – Adenocarcinoma and ductal carcinoma of pancreas
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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