No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
First used in FinnGen datafreeze
DF8
Similar endpoints
↥List of similar endpoints to
Osteosarcoma
based on the number of shared cases.
Similar with more cases:
- Osteosarcoma
- Malignant neoplasm of bone and articular cartilage
- Malignant neoplasm of bone and articular cartilage
- Malignant neoplasm
- Malignant neoplasm
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 717 | 278 | 426 |
| Only index persons | 401 | 168 | 233 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 21.08 | 19.75 | 21.26 |
| Only index persons | 19.42 | 17.67 | 20.68 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 69 | 28 | 41 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | 24.08 | 17.27 | 28.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint C3_OSTEOSARCOMA_EXALLC and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_OSTEOSARCOMA_EXALLC | 9.305 [3.91, 22.16] | < 0.001 |
| Birth year | 0.985 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 146 males with C3_OSTEOSARCOMA_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_OSTEOSARCOMA_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 1.411% |
| 5 | No data | 10.108% |
| 10 | No data | 24.154% |
| 15 | No data | 39.754% |
| 20 | No data | 58.174% |
Relationships between endpoints
↥Index endpoint: C3_OSTEOSARCOMA_EXALLC – Osteosarcoma
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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