No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF4
Similar endpoints
↥List of similar endpoints to
Malignant neoplasm of bone and articular cartilage
based on the number of shared cases.
Similar with more cases:
- Malignant neoplasm of bone and articular cartilage
- Malignant neoplasm
- Malignant neoplasm
- Any event in cancer register
- Malignant neoplasm, wide definition for exclusion
Similar with less cases:
- Malignant neoplasm of bone and articular cartilage
- Malignant neoplasm of bone and articular cartilage of other and unspecified sites
- Malignant neoplasm of bone and articular cartilage of other and unspecified sites
- Malignant neoplasm of bone and articular cartilage of limbs
- Malignant neoplasm of bone and articular cartilage of limbs
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2903 | 1189 | 1664 |
| Only index persons | 1734 | 767 | 967 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.03 | 0.05 |
| Only index persons | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 46.60 | 47.72 | 45.49 |
| Only index persons | 46.10 | 47.46 | 45.03 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 281 | 121 | 160 |
| Unadjusted period prevalence (%) | 0.07 | 0.05 | 0.08 |
| Median age at first event (years) | 50.68 | 48.61 | 52.24 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint C3_BONE_CARTILAGE_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_BONE_CARTILAGE_EXALLC | 4.8 [3.29, 7.0] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.062 |
During the follow-up period (1.1.1998 — 31.12.2019), 162 out of 517 females with C3_BONE_CARTILAGE_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_BONE_CARTILAGE_EXALLC | 4.667 [3.39, 6.43] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 304 out of 721 males with C3_BONE_CARTILAGE_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_BONE_CARTILAGE_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.402% | 0.957% |
| 5 | 2.356% | 6.071% |
| 10 | 6.282% | 14.203% |
| 15 | 11.85% | 25.332% |
| 20 | 19.528% | 40.095% |
Relationships between endpoints
↥Index endpoint: C3_BONE_CARTILAGE_EXALLC – Malignant neoplasm of bone and articular cartilage
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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