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Malignant neoplasm of nasopharynx

Endpoint Browser PheWeb

C3_NASOPHARYNX_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C11
  • Cause of death: ICD-9 — 147
  • Cause of death: ICD-8 — 147
  • Cancer registry: Topography ICD-O-3 — C11
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 860 287 554
Only index persons 426 152 274
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.02
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 58.86 61.31 57.47
Only index persons 58.25 59.21 57.72

-FinnGen-

Key figures

All Female Male
Number of individuals 89 38 51
Unadjusted period prevalence (%) 0.02 0.01 0.03
Median age at first event (years) 62.14 57.12 65.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint C3_NASOPHARYNX_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_NASOPHARYNX_EXALLC 5.957 [2.67, 13.3] < 0.001
Birth year 0.992 [0.98, 1.0] 0.063

During the follow-up period (1.1.1998 — 31.12.2019), 63 out of 137 females with C3_NASOPHARYNX_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_NASOPHARYNX_EXALLC 4.803 [3.38, 6.82] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 141 out of 279 males with C3_NASOPHARYNX_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_NASOPHARYNX_EXALLC.

N-year risk Females Males
1 0.351% 0.716%
5 2.809% 5.366%
10 7.504% 13.218%
15 14.172% 24.424%
20 23.777% 38.34%

Relationships between endpoints

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Index endpoint: C3_NASOPHARYNX_EXALLC – Malignant neoplasm of nasopharynx

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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