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Malignant neoplasm of lip

Endpoint Browser PheWeb

C3_LIP_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C00&
  • Cause of death: ICD-9 — 140
  • Cause of death: ICD-8 — 140
  • Cancer registry: Topography ICD-O-3 — C00
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5123 1032 3949
Only index persons 2162 666 1496
Unadjusted period prevalence (%)
Whole population 0.10 0.03 0.11
Only index persons 0.05 0.02 0.06
Median age at first event (years)
Whole population 67.63 75.25 65.76
Only index persons 69.86 75.01 67.57

-FinnGen-

Key figures

All Female Male
Number of individuals 246 53 193
Unadjusted period prevalence (%) 0.08 0.02 0.10
Median age at first event (years) 67.29 71.72 66.07

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint C3_LIP_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_LIP_EXALLC 1.415 [1.19, 1.69] < 0.001
Birth year 0.994 [0.98, 1.0] 0.154

During the follow-up period (1.1.1998 — 31.12.2019), 356 out of 618 females with C3_LIP_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_LIP_EXALLC 1.254 [1.08, 1.46] 0.004
Birth year 0.983 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 657 out of 1175 males with C3_LIP_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_LIP_EXALLC.

N-year risk Females Males
1 0.126% 0.223%
5 0.813% 1.328%
10 2.097% 3.374%
15 3.818% 6.475%
20 6.673% 10.707%

Relationships between endpoints

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Index endpoint: C3_LIP_EXALLC – Malignant neoplasm of lip

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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