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Malignant neoplasm of hypopharynx

Endpoint Browser PheWeb

C3_HYPOPHARYNX_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C12&, C13
  • Cause of death: ICD-9 — 148
  • Cause of death: ICD-8 — 148
  • Cancer registry: Topography ICD-O-3 — C1[23]
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1137 228 858
Only index persons 532 93 439
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.01 0.00 0.02
Median age at first event (years)
Whole population 64.89 64.13 65.19
Only index persons 66.64 64.87 67.02

-FinnGen-

Key figures

All Female Male
Number of individuals 124 13 111
Unadjusted period prevalence (%) 0.05 0.01 0.06
Median age at first event (years) 69.16 69.73 69.09

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint C3_HYPOPHARYNX_EXALLC and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
C3_HYPOPHARYNX_EXALLC 12.246 [7.1, 21.12] < 0.001
Birth year 0.991 [0.98, 1.0] 0.056

During the follow-up period (1.1.1998 — 31.12.2019), 405 out of 514 males with C3_HYPOPHARYNX_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_HYPOPHARYNX_EXALLC.

N-year risk Females Males
1 No data 2.763%
5 No data 15.419%
10 No data 33.042%
15 No data 54.845%
20 No data 74.674%

Relationships between endpoints

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Index endpoint: C3_HYPOPHARYNX_EXALLC – Malignant neoplasm of hypopharynx

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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