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Alcohol withdrawal state with delirium 

EFO Endpoint Browser PheWeb

ALCODELIRIUM

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F10.4
  • Hospital discharge: ICD-9 — 2912A
  • Hospital discharge: ICD-8 — 29100
  • Cause of death: ICD-10 — F10.4
  • Cause of death: ICD-9 — 2912A
  • Cause of death: ICD-8 — 29100

2 out of 7 registries used, show all original rules.

2437

4. Check minimum number of events

None

2437

5. Include endpoints

None

2437

6. Filter based on genotype QC (FinnGen only)

2376

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 39785 7076 32217
Only index persons 29857 5782 24075
Unadjusted period prevalence (%)
Whole population 0.77 0.20 0.90
Only index persons 0.78 0.21 0.92
Median age at first event (years)
Whole population 51.40 52.55 51.13
Only index persons 52.17 53.20 51.93

-FinnGen-

Key figures

All Female Male
Number of individuals 2376 433 1943
Unadjusted period prevalence (%) 0.83 0.17 0.98
Median age at first event (years) 52.19 51.05 52.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint ALCODELIRIUM and mortality.

Females

Parameter HR [95% CI] p-value
ALCODELIRIUM 6.93 [6.19, 7.76] < 0.001
Birth year 0.996 [0.99, 1.0] 0.334

During the follow-up period (1.1.1998 — 31.12.2019), 2106 out of 5571 females with ALCODELIRIUM died.

Males

Parameter HR [95% CI] p-value
ALCODELIRIUM 6.047 [5.53, 6.61] < 0.001
Birth year 0.985 [0.98, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 10963 out of 23654 males with ALCODELIRIUM died.

Mortality risk

Mortality risk for people of age

years, who have ALCODELIRIUM.

N-year risk Females Males
1 0.591% 1.149%
5 4.139% 5.773%
10 9.387% 14.449%
15 17.934% 25.698%
20 29.252% 40.76%

Relationships between endpoints

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Index endpoint: ALCODELIRIUM – Alcohol withdrawal state with delirium 

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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