animal viral hepatitis: A hepatitis that involves viral infection of an animal causing inflammation of the liver.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2768 |
4. Check minimum number of eventsNone |
2768 |
5. Include endpoints |
2768 |
6. Filter based on genotype QC (FinnGen only) |
2519 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Viral hepatitis
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 31514 | 12176 | 18725 |
| Only index persons | 28006 | 11243 | 16763 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.46 | 0.35 | 0.52 |
| Only index persons | 0.55 | 0.41 | 0.64 |
| Median age at first event (years) | |||
| Whole population | 32.94 | 31.00 | 34.14 |
| Only index persons | 32.37 | 30.40 | 33.69 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2519 | 1147 | 1372 |
| Unadjusted period prevalence (%) | 0.58 | 0.45 | 0.69 |
| Median age at first event (years) | 34.73 | 32.75 | 36.39 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint AB1_VIRAL_HEPATITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_VIRAL_HEPATITIS | 4.452 [3.77, 5.25] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.029 |
During the follow-up period (1.1.1998 — 31.12.2019), 890 out of 8567 females with AB1_VIRAL_HEPATITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| AB1_VIRAL_HEPATITIS | 5.976 [5.33, 6.7] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 2626 out of 13772 males with AB1_VIRAL_HEPATITIS died.
Mortality risk
Mortality risk for people of age
years, who have AB1_VIRAL_HEPATITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.319% | 0.893% |
| 5 | 2.193% | 6.033% |
| 10 | 5.343% | 15.19% |
| 15 | 10.523% | 28.411% |
| 20 | 17.402% | 43.684% |
Relationships between endpoints
↥Index endpoint: AB1_VIRAL_HEPATITIS – Viral hepatitis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data