Acute hepatitis A

AB1_HEPATITIS_A

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B15
  • Hospital discharge: ICD-9 070[0-1]
  • Cause of death: ICD-10 B15
  • Cause of death: ICD-9 070[0-1]

2 out of 7 registries used, show all original rules.

150

4. Check minimum number of events

None

150

5. Include endpoints

None

150

6. Filter based on genotype QC (FinnGen only)

141

Control definitions (FinnGen only)

Control exclude AB1_VIRAL_HEPATITIS

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 B15-B19
Name in latin Hepatitis A acuta

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1602 688 896
Only index persons 1328 598 730
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.03
Only index persons 0.03 0.02 0.03
Median age at first event (years)
Whole population 36.85 37.94 35.93
Only index persons 34.38 35.37 33.56

-FinnGen-

Key figures

All Female Male
Number of individuals 141 72 69
Unadjusted period prevalence (%) 0.03 0.03 0.03
Median age at first event (years) 39.55 39.51 39.59

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint AB1_HEPATITIS_A and mortality.

Females

Parameter HR [95% CI] p-value
AB1_HEPATITIS_A 2.036 [1.4, 2.96] < 0.001
Birth year 0.997 [0.99, 1.01] 0.506

During the follow-up period (1.1.1998 — 31.12.2019), 51 out of 336 females with AB1_HEPATITIS_A died.

Males

Parameter HR [95% CI] p-value
AB1_HEPATITIS_A 3.07 [2.26, 4.18] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 110 out of 473 males with AB1_HEPATITIS_A died.

Mortality risk

Mortality risk for people of age

years, who have AB1_HEPATITIS_A.

N-year risk Females Males
1 0.231% 0.453%
5 1.239% 3.157%
10 3.161% 7.868%
15 6.288% 14.48%
20 11.069% 23.486%

Relationships between endpoints

Index endpoint: AB1_HEPATITIS_A – Acute hepatitis A

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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