asthma: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
163 |
4. Check minimum number of eventsNone |
163 |
5. Include endpointsNone |
163 |
6. Filter based on genotype QC (FinnGen only) |
156 |
Control definitions (FinnGen only)
Control exclude
IBD_BACT_INTEST_INFECTIONS
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
A04
Name in latin
Enteritis a Yersinia enterocolitica
Similar endpoints
↥List of similar endpoints to
Enteritis due to Yersinia enterocolitica
based on the number of shared cases.
Similar with more cases:
- Bacterial intestinal infections, IBD co-morbidities
- Infections, IBD-co-morbidities
- Intestinal infectious diseases
- Certain infectious and parasitic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1504 | 800 | 693 |
| Only index persons | 1361 | 727 | 634 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 40.57 | 43.10 | 37.23 |
| Only index persons | 39.86 | 42.41 | 36.93 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 156 | 87 | 69 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 44.44 | 40.20 | 49.78 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint YERSINIAENTERITIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| YERSINIAENTERITIS | 1.696 [1.28, 2.24] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.191 |
During the follow-up period (1.1.1998 — 31.12.2019), 105 out of 626 females with YERSINIAENTERITIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| YERSINIAENTERITIS | 1.525 [1.11, 2.1] | 0.01 |
| Birth year | 0.988 [0.98, 1.0] | 0.011 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 526 males with YERSINIAENTERITIS died.
Mortality risk
Mortality risk for people of age
years, who have YERSINIAENTERITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.154% | 0.26% |
| 5 | 1.027% | 1.703% |
| 10 | 2.513% | 4.274% |
| 15 | 4.725% | 8.398% |
| 20 | 8.16% | 14.254% |
Relationships between endpoints
↥Index endpoint: YERSINIAENTERITIS – Enteritis due to Yersinia enterocolitica
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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