Ulcerative enterocolitis

ULCERENTER

ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 K51.0
  • Cause of death: ICD-10 K51.0

2 out of 7 registries used, show all original rules.

1128

4. Check minimum number of events

None

1128

5. Include endpoints

None

1128

6. Filter based on genotype QC (FinnGen only)

1091

Control definitions (FinnGen only)

Control exclude K11_ENERCOLNONINF

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 K51
Name in latin Enterocolitis ulcerosa [chronica]

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 7478 3539 3905
Only index persons 6872 3325 3547
Unadjusted period prevalence (%)
Whole population 0.11 0.10 0.11
Only index persons 0.13 0.12 0.14
Median age at first event (years)
Whole population 43.87 41.69 45.68
Only index persons 42.10 40.37 43.72

-FinnGen-

Key figures

All Female Male
Number of individuals 1091 581 510
Unadjusted period prevalence (%) 0.24 0.23 0.26
Median age at first event (years) 42.14 36.63 48.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint ULCERENTER and mortality.

Females

Parameter HR [95% CI] p-value
ULCERENTER 1.635 [1.44, 1.86] < 0.001
Birth year 0.996 [0.99, 1.0] 0.321

During the follow-up period (1.1.1998 — 31.12.2019), 499 out of 3272 females with ULCERENTER died.

Males

Parameter HR [95% CI] p-value
ULCERENTER 1.552 [1.39, 1.74] < 0.001
Birth year 0.987 [0.98, 1.0] 0.017

During the follow-up period (1.1.1998 — 31.12.2019), 724 out of 3513 males with ULCERENTER died.

Mortality risk

Mortality risk for people of age

years, who have ULCERENTER.

N-year risk Females Males
1 0.182% 0.27%
5 0.994% 1.839%
10 2.632% 4.43%
15 5.101% 8.5%
20 8.421% 14.2%

Relationships between endpoints

Index endpoint: ULCERENTER – Ulcerative enterocolitis

GWS hits: 3

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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