ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1128 |
4. Check minimum number of eventsNone |
1128 |
5. Include endpointsNone |
1128 |
6. Filter based on genotype QC (FinnGen only) |
1091 |
Control definitions (FinnGen only)
Extra metadata
Similar endpoints
↥List of similar endpoints to
Ulcerative enterocolitis
based on the number of shared cases.
Similar with more cases:
- Ulcerative colitis
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
None
Case counts by codes
↥Summary Statistics
↥-FinRegistry-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | |||
Whole population | 7478 | 3539 | 3905 |
Only index persons | 6872 | 3325 | 3547 |
Unadjusted period prevalence (%) | |||
Whole population | 0.11 | 0.10 | 0.11 |
Only index persons | 0.13 | 0.12 | 0.14 |
Median age at first event (years) | |||
Whole population | 43.87 | 41.69 | 45.68 |
Only index persons | 42.10 | 40.37 | 43.72 |
-FinnGen-
Key figures
All | Female | Male | |
---|---|---|---|
Number of individuals | 1091 | 581 | 510 |
Unadjusted period prevalence (%) | 0.24 | 0.23 | 0.26 |
Median age at first event (years) | 42.14 | 36.63 | 48.41 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint ULCERENTER and mortality.
Females
Parameter | HR [95% CI] | p-value |
---|---|---|
ULCERENTER | 1.635 [1.44, 1.86] | < 0.001 |
Birth year | 0.996 [0.99, 1.0] | 0.321 |
During the follow-up period (1.1.1998 — 31.12.2019), 499 out of 3272 females with ULCERENTER died.
Males
Parameter | HR [95% CI] | p-value |
---|---|---|
ULCERENTER | 1.552 [1.39, 1.74] | < 0.001 |
Birth year | 0.987 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 724 out of 3513 males with ULCERENTER died.
Mortality risk
Mortality risk for people of age
years, who have ULCERENTER.N-year risk | Females | Males |
---|---|---|
1 | 0.182% | 0.27% |
5 | 0.994% | 1.839% |
10 | 2.632% | 4.43% |
15 | 5.101% | 8.5% |
20 | 8.421% | 14.2% |
Relationships between endpoints
↥Index endpoint: ULCERENTER – Ulcerative enterocolitis
GWS hits: 3